Understanding Alzheimer’s through cellular energy
How the brain uses energy
The brain relies on a constant supply of energy to function. This energy is produced within cells by structures called mitochondria. When this system is working properly, neurons can communicate, repair, and maintain normal function.
What Changes with Alzheimer’s
Research shows that Alzheimer’s disease is associated with:
Reduced energy metabolism in the brain
Impaired mitochondrial function
Increased cellular stress
These changes may contribute to the breakdown of neuronal health over time.
Bioenergetics Explained
Bioenergetics describes how cells create and use energy. In the brain, energy is not optional. It powers every signal, every connection, and every repair process.
When that system falters, neurons become vulnerable.
Increasingly, research suggests this system breakdown in cellular energy may be a key factor in Alzheimer’s disease.
A Shift in Perspective
The Mitochondrial Cascade Hypothesis
This research suggests that disruptions in cellular energy may occur early in the disease process, potentially before the appearance of amyloid plaques and tau tangles.
Rather than being the starting point, those markers may be downstream efforts of earlier dysfunction.
Take a deep dive into the science by reading our published research.
Our Approach
Aerobyx is developing therapies designed to support mitochondrial function and improve how neurons produce and use energy. By focusing on these foundational processes, this approach aims to address disease biology earlier.
Because mitochondrial dysfunction is observed across multiple neurodegenerative diseases, this approach may have broader implications beyond Alzheimer’s.